Search results for "Calcium dobesilate"

showing 2 items of 2 documents

Diabetic retinopathy: Monitoring of the macro and microrheological parameters after oral administration of a single dose of calcium dobesilate (Doxiu…

1991

Chemotherapymedicine.medical_specialtyPhysiologybusiness.industrymedicine.medical_treatmentEye diseaseCalcium dobesilateHematologyDiabetic retinopathymedicine.diseaseSurgeryOral administrationPhysiology (medical)Diabetes mellitusOphthalmologymedicineCardiology and Cardiovascular MedicineComplicationbusinessmedicine.drugRetinopathyClinical Hemorheology and Microcirculation
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Mechanisms of interference of p-diphenols with the Trinder reaction

2020

p-Diphenols, such as homogentisic acid, gentisic acid, etamsylate, and calcium dobesilate, interfere with diagnostic tests utilizing the Trinder reaction but the mechanisms of these effects are not fully understood. We observed substantial differences both in oxidation of p-diphenols by horseradish peroxidase and their influence on oxidation of 4-aminoantipyrine and various phenolic substrates. Homogentisic acid was rapidly oxidized by the enzyme and completely blocked chromophore formation. Enzymatic oxidation of the remaining p-diphenols was slow and they only moderately inhibited chromophore formation. However, in the presence of standard substrates all tested p-diphenols were rapidly co…

RadicalSubstituentElectronsPhotochemistry01 natural sciencesBiochemistryRedoxHorseradish peroxidaseHomogentisic acidchemistry.chemical_compoundGentisic acidPhenolsDrug DiscoveryBenzoquinonesHomogentisic acidGentisic acidEnzymatic assay interferenceHydrogen peroxideMolecular BiologyHorseradish PeroxidaseCalcium dobesilatebiology010405 organic chemistryOrganic ChemistryHydrogen PeroxideChromophoreEtamsylate0104 chemical sciencesAmpyrone010404 medicinal & biomolecular chemistrychemistrySpectrophotometrybiology.proteinOxidation-ReductionTrinder reactionBioorganic Chemistry
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